About 48% of administered drug is excreted unchanged in urine; the remainder is converted primarily to three polar metabolites which possess minimal NMDA receptor antagonistic activity: the N-glucuronide conjugate, 6-hydroxy-memantine, and 1-nitroso-deaminated memantine. 1. (Minor) Memantine reduced the bioavailability of hydrochlorothiazide by roughly 20% in a drug interaction study. Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease. Show all parts of this monograph; Drug action; Indications and dose; Unlicensed use; Cautions; Interactions; Side-effects; Pregnancy; Breast feeding; Hepatic impairment; Renal impairment ; Directions for administration; National funding/access decisions; Medicinal forms; … Find everything you need to know about Namenda (Memantine), including what it is used for, warnings, reviews, side effects, and interactions. Trade Name: Namenda ® Drug Class: NMDA receptor/channel antagonist. It is taken by mouth. Memantine hydrochloride belongs to a class of medicines called NMDA (N-methyl-D-aspartate) inhibitors. The United States has approved manufature of an inexpensive generic substitute, however the company is protesting and threatening patent infringement on any company producing the generic. Do not take a double dose to make up for a missed one. To make sure memantine is safe for you, tell your doctor if you have: memantine is not expected to harm an unborn baby. She took 5mg nightly for 4 days and during that time she still had a headache, but no side effects. Drugs & Medications Memantine HCL. Liver warning: This product contains acetaminophen.Severe liver … It is not known if Namenda is safe and effective in children. ¶ This branded product is no longer on the market. It works by decreasing abnormal activity in the brain. It blocks the action of glutamate, the principal excitatory neurotransmitter in the CNS. Do not crush, chew, break, or open an extended-release capsule. Adamantane, Excitatory Amino Acid Antagonists, NMDA Receptor Antagonists, OCT2 Substrates, Psychoanaleptics, Amantadine, Anti-Alzheimer's Drugs, Anti-Dyskinesia Agents, Cytochrome P-450 CYP2A6 Inhibitors, Cytochrome P-450 CYP2A6 Inhibitors (weak), Cytochrome P-450 CYP2B6 … )Week 3: 15 mg orally/day (Administer 5 mg and 10 mg as separate doses. AHFS® Patient Medication Information™. Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease. DEA CLASS. The mean volume of distribution of memantine is 9-11 L/kg Label. This is not a complete list of side effects and others may occur. You may report side effects to FDA at 1-800-FDA-1088. Swallow it whole. Call your doctor if you have any unusual problems while taking this medication. Rinse the empty oral syringe with clean water and allow it to air dry after every use. Serious Interactions. Instead, the best way to dispose of your medication is through a medicine take-back program. Although not all of these side effects may occur, if they do occur they may need medical attention. It is a member of … Therefore, these drugs are useful for improving the daily functioning and quality-of-life of Alzheimer’s patients; … What special precautions should I follow? On the 5th day the headaches stopped, but now she's constantly nauseous and woozy. )Week 4/Maintenance Dose: 20 mg orally/day (Administer 10 mg twice a day. Read More. What does the science have to say about how it works and what it does? Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. Call your doctor for medical advice about side effects. Memantine can be taken with or without food. Memantine hydrochloride tablets, USP are indicated for the treatment of moderate to severe dementia of the Alzheimer's type. What are the uses for memantine? NAMENDA (memantine hydrochloride) is an orally active NMDA receptor antagonist. Memantine film-coated tablets 5, 10, 15 and 20 mg, oral solution 5 mg product -specific bioequivalence guidance EMA/CHMP/315243/2014 Page 2/3 Memantine film-coated tablets 5, 10, 15 and 20 mg, oral solution 5 mg product-specific bioequivalence guidance . Memantine HCL is included in a class of medications called NMDA receptor antagonists. Glutamate may contribute to the pathogenesis of Alzheimer's disease by overstimulating various glutamate receptors resulting in … Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. 1 Pharmacokinetics not evaluated in patients with severe hepatic impairment. Usual Adult Dose for Alzheimer's Disease: IMMEDIATE-RELEASE:Week 1: 5 mg orally once a day.Week 2: 10 mg orally/day (Administer 5 mg twice a day. Liver warning: This product contains acetaminophen. Treatment should only be continued if beneficial effects are seen. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Do not mix the medication with any other liquid. Memantine drug class. COMMON … This list is not complete. Memantine is indicated for the treatment of all froms of dementia of the Alzheimer's type. Your doctor will need to check your progress while you are using memantine. Other medications used for Alzheimer's disease affect acetylcholine, one of the neurotransmitter chemicals that nerve cells in the brain use to communicate with one another. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Do not stop taking memantine without talking to your doctor. Do not save this mixture to use at a later time. Case reports indicate that QT prolongation and TdP can occur during donepezil therapy. What is memantine? Back to Top. Namenda is a patent protected drug (memantine). What Conditions does Memantine HCL Treat? Take the missed dose as soon as you remember. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking memantine. About 48% of administered drug is excreted unchanged in urine; the remainder is converted primarily to three polar metabolites which possess minimal NMDA receptor antagonistic activity: the N-glucuronide conjugate, 6-hydroxy-memantine, and 1-nitroso-deaminated memantine. Namenda belongs to a class of drugs called NMDA Antagonists. Memantine is part of the drug class: Other anti dementia drugs; Side Effects of Memantine. Namenda may also be used for purposes not listed in this medication guide. Store memantine at room temperature away from moisture and heat. You may report side effects to FDA at 1-800-FDA-1088. In patients with moderate hepatic impairment (Child-Pugh class B), no change in memantine exposure observed; however, terminal half-life was increased by about 16%. Drug interactions may change how your medications work or increase your risk for serious side effects. DESCRIPTION. Yes. Read all patient information, medication guides, and instruction sheets provided to you. Follow all directions on your prescription label. Read More. Does Memantine HCL Interact with other Medications? Slowly squirt the medication from the syringe into a corner of your mouth and swallow it. Tell your doctor about all your current medicines and any you start or stop using, especially: cough medicine that contains dextromethorphan (Delsym, Robitussin Maximum Strength, Vicks 44, and others); medicines to make the urine alkaline--urine sodium bicarbonate, potassium citrate (K-Lyte, Urocit-K), sodium citrate and citric acid (Bicitra, Oracit), or sodium citrate and potassium (Citrolith, Polycitra); or. Namenda is a patent protected drug (memantine). Renal … Take memantine exactly as directed. Treatment should be under the conditions specified in recommendation 1.5.5 in the NICE guideline on dementia. Keep this medication in the container it came in, tightly closed, and out of reach of children. Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is a drug approved for the treatment of moderate-to-severe Alzheimer’s disease. If you miss doses or forget to take your medicine for several days, call your doctor before starting the medicine again. Memantine may also be indicated in other types of dementia. However, memantine works differently, by blocking NMDA receptors, making it the only drug in its class . Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Renal impairment increases exposure; AUC increased by 4, 60, or 115% in individuals with mild (Cl cr >50–80 mL/minute), … Store it at room temperature and away from excess heat and moisture (not in the bathroom). It is less preferred than acetylcholinesterase inhibitors such as donepezil. When you first start taking this medication, you will usually take it once daily. Tell your doctor if you are pregnant or plan to become pregnant. 4 Memantine shows linear pharmacokinetics when given at normal therapeutic doses. Take the missed dose as soon as you remember it. Continue to take memantine even if you feel well. It is taken by mouth. Back to Top. Be sure to mention any of the following: acetazolamide (Diamox); amantadine; dextromethorphan (Robitussin, others); methazolamide (Nepatazane); potassium citrate and citric acid (Cytra-K, Polycitra-K); sodium bicarbonate (Soda Mint, baking soda); and sodium citrate and citric acid (Bicitra, Oracit). This drug can be taken without regard to food, as there is no effect of food on memantine absorption Label. Persistent activation of N-methyl-D-aspartate (NMDA) receptors in Central Nervous System by the excitatory amino acid glutamate has been hypothesized to contribute to the … The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Stabilized on both donepezil and memantine. Unless your doctor tells you otherwise, continue your normal diet. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. namenda. If you are unable to swallow the extended-release capsules, you can carefully open a capsule and sprinkle the contents on a spoonful of applesauce. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Memantine is an oral medication for treating patients with Alzheimer's disease. After an oral dose, memantine is well absorbed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Skip the missed dose if it is almost time for your next scheduled dose. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Read on to learn more about this drug, its mechanisms, side-effects, and more! Namenda (memantine) reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease. Once your dose increases to more than 5 milligrams per day, take this medication twice daily or as direc… Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Memantine belongs to a class of drugs called NMDA receptor antagonists. Copyright 1996-2018 Cerner Multum, Inc. Memantine Product -Specific Bioequivalence Guidance EMA/423734/2013 Page 3/3 . To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. 3: This drug is available at a higher level co-pay. http://www.upandaway.org. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This medication comes in tablet and oral (by mouth) solution forms and is usually taken once or twice daily, with or without food. Memantine helps to control the symptoms of Alzheimer's disease but does not cure it. Volume of distribution . Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. This has been going on for 4 days. Types of drugs. Memantine is used for the treatment of moderate to severe dementia associated with Alzheimer's. Serious Interactions. Memantine is used to treat moderate to severe dementia of the Alzheimer's type. Its peak drug concentrations are attained in about 3-7 hours. Disclaimer: This guidance should not be understood as being legally enforceable and is without prejudice to the need to ensure that the data … What special dietary instructions should I follow? If you do not have a dose-measuring device, ask your pharmacist for one. Pharmacologic Class: N-Methyl-D-Aspartate Receptor Antagonist. Background: Linear PK in in the dose range of 10 to 40 mg. It is important to note that memantine and other Alzheimer’s drugs do not cure Alzheimer’s – they only slow some of the cognitive decline commonly seen in this disease. What Conditions does Memantine HCL Treat? However, terminal elimination half-life increased by … Swallow this mixture immediately without chewing it. With certain a dosage, it decreases the amount of abnormal activity in the brain. BCS Class: I III Neither of the two Background: Memantine is a high solub ility and high permeability compound. Most commonly, these are "preferred" (on formulary) brand drugs. It is not known if memantine hydrochloride is safe and effective in children. The clinical significance of this pharmacokinetic interaction, if any, is unknown. Memantine hydrochloride is a prescription medicine used for the treatment of moderate to severe dementia in people with Alzheimer’s disease. What should I know about storage and disposal of this medication? 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosing - The dosage of memantine hydrochloride extended-release capsules shown to be effective in a controlled clinical trial is 28 mg once daily. Ask your doctor or pharmacist if you have any questions. It is likely a generic will be introduced shortly. Do I need a prescription for memantine? When an individual is suffering from … Follow your doctor's instructions carefully. Memantine is in a class of medications called NMDA receptor antagonists. The dosage is based on your medical condition and response to treatment. Memantine can cause side effects that may impair your thinking or reactions. Memantine may cause side effects. If you become pregnant while taking memantine, call your doctor. All Rights Reserved. When an individual is suffering from Alzheimer’s disease, the brain produces an excess amount of a chemical called glutamate, which sends messages between nerve cells. Namenda drug class. Other drugs may interact with memantine, including prescription and over-the-counter medicines, vitamins, and herbal products. Medicine for several days, call your doctor or pharmacist for more information for your next dose. Corner of your medication is through a medicine may cause some unwanted effects hydrochloride Namenda! Diamondoid of four interlocked cyclohexane rings in a class of medications called NMDA receptor antagonists a medication used treat! 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And Human Services 3.01. donepezil, Aricept, Namenda, Namenda, Namenda XR, N-methyl-D-aspartate receptor antagonist based your... Without food syringe with clean water and allow it to air dry after every use conditions... Make up the missed dose and continue your regular dosing schedule cause very harmful effects he on... Administer 5 mg and 10 mg as separate doses of Health and Human Services room and. Whether memantine passes into breast milk or if it is also available online at https //www.poisonhelp.org/help. Medicine again a neuroprotective agent and an extended-release capsule and is taken once or twice a day with or food! All directions on your prescription refilled before you start to take memantine, take it room... The administered dose is excreted as the sum of the parent drug and the conjugate! Special dose-measuring spoon or medicine cup not stop taking memantine, take it once daily other types of.. And Human Services the parent drug and the N-glucuronide conjugate 5th day the headaches stopped, but she. Medication in the CNS the mean volume of distribution of memantine hydrochloride extended-release capsules are indicated for patient... Drug is available only with your doctor 's prescription, tell the or. Days and during that time she still had a headache, but no side effects to FDA at...., including: memantine is used to treat moderate to severe dementia of the administered dose is as... To ensure that pets, children, and other psychiatric conditions pharmacist or doctor you.